Muslims believe that Jesus is not God and that the concept of the Trinity is incompatible with Islamic teachings.

The New Testament writings ascribe titles and roles to Jesus that are uniquely associated with God Almighty, such as being the 'First and the Last' and coming to judge the nations. For instance, Isaiah 44:6 and Isaiah 48:12 declare that Yahweh is the first and the last, a title that is applied to Jesus in Revelation 22:13. Furthermore, the Hebrew Bible describes God riding on the clouds, a motif that is echoed in the New Testament where Jesus is depicted as coming on the clouds of heaven (Matthew 24:30). This connection between Jesus and the divine attributes of God supports the claim of his deity. Moreover, the prophecies concerning God's coming to save and judge are fulfilled in Jesus, who is referred to as the Savior in Isaiah 62:11. The New Testament reinforces this by presenting Jesus as the one who brings good news and rewards, paralleling the descriptions of Yahweh’s actions in the Old Testament. The culmination of these prophecies is seen in the events surrounding Jesus' life, death, and resurrection, which Christians believe affirm his divine nature. Additionally, the claim that Jesus cannot be God contradicts the Christian understanding of the Trinity, which posits that God exists as three persons in one essence. This mystery is foundational to Christian belief and is supported by various passages in the New Testament, such as John 1:1, which states, 'In the beginning was the Word, and the Word was with God, and the Word was God.' Thus, the Christian perspective maintains that Jesus' divinity is not only a theological assertion but is deeply rooted in scriptural prophecy and fulfillment.